Altered microRNA profiles of testicular biopsies from patients with nonobstructive azoospermia
نویسندگان
چکیده
منابع مشابه
Altered microRNA expression in patients with non-obstructive azoospermia
BACKGROUND MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are indicated to play essential roles in spermatogenesis. However, little is known about the expression patterns or function of miRNAs in human testes involved in infertility. METHODS In this study, the miRNA expression profiles of testes of patients with non-obstructive azoospermia (NOA) and normal controls were perfor...
متن کاملO-40: MTHFR Promoter Hypermethylationin Testicular Biopsies of patients with Non-Azoospermia: the Role of Epigeneticsin Male Infertility
Background: MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility. Materials and Methods: DNA from peripheral blood (PB) samples of 50 patients with NOA and 50 fertile men (controls) as well as DNA from testicular biopsies of 32 patients with NOA and five patients with obstructive azoospemia, but normal s...
متن کاملPrediction of successful sperm retrieval in patients with nonobstructive azoospermia.
INTRODUCTION Our aim was to evaluate the predictive values of factors that indicate successful sperm retrieval in men with nonobstructive azoospermia. MATERIALS AND METHODS We evaluated 85 infertile men with nonobstructive azoospermia who underwent multiple bilateral testicular biopsies. Factors including age, infertility period, surgical history, testicular volume, testicular consistency, se...
متن کاملFactors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients
OBJECTIVE Azoospermia owing to testicular disorders is the most severe manifestation of male infertility. The main concern for patients with nonobstructive azoospermia (NOA) is the probability of successful sperm retrieval following testicular sperm extraction (TESE). Therefore, the goal of this study was to determine predictive factors correlated with sperm retrieval. METHODS We assessed the...
متن کاملSurgical management of nonobstructive azoospermia
Nonobstructive azoospermia (NOA) is characterized by the complete absence of sperm in the ejaculate due to testicular failure. The evaluation and management of patients with NOA offer a challenge to the reproductive urologist. In the era of in vitro fertilization with intracytoplasmic sperm injection, surgical sperm extraction techniques can afford men with NOA biologic paternity. To provide a ...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2020
ISSN: 1008-682X
DOI: 10.4103/aja.aja_35_19